Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch
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The tetracycline aptamer is an in vitro selected RNA that binds to the antibiotic with the highest known affinity of an artificial RNA for a small molecule (Kd approximately 0.8 nM). It is one of few aptamers known to be capable of modulating gene expression i... ...
