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Behavioural brain research. 2008 Nov 21;193(2):174-82. doi: 10.1016/j.bbr.2008.05.008 Q22.32025

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

中年载脂蛋白ε4替代替换型小鼠在多种空间记忆任务中出现的记忆缺失缺陷 翻译改进

Alexandra Bour  1, Jeannette Grootendorst, Elise Vogel, Christian Kelche, Jean-Cosme Dodart, Kelly Bales, Pierre-Henri Moreau, Patrick M Sullivan, Chantal Mathis

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  • 1 Laboratoire de Neurosciences Comportementales et Cognitives, Université Louis Pasteur, CNRS-UMR 7191, IFR 37, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France.
  • DOI: 10.1016/j.bbr.2008.05.008 PMID: 18572260

    摘要 Ai翻译

    Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent role of apoE in cognitive processes was studied in human apoE targeted-replacement (TR) mice. These mice express either the human apoE3 or ap... ...点击完成人机验证后继续浏览
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    期刊名:Behavioural brain research

    缩写:BEHAV BRAIN RES

    ISSN:0166-4328

    e-ISSN:1872-7549

    IF/分区:2.3/Q2

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    Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks