Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1
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Human cytochrome P450 46A1 (CYP46A1) is one of the key enzymes in cholesterol homeostasis in the brain. The crystallization and heavy-atom structure solution of an active truncated CYP46A1 in complex with the high-affinity substrate analogue cholesterol-3-sulf... ...
