Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis
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Wye bases are tricyclic bases that are found in archaeal and eukaryotic tRNAs. The most modified wye base, wybutosine, which appears at position 37 (the 3'-adjacent position to the anticodon), is known to be important for translational reading-frame maintenanc... ...