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Free radical biology & medicine. 2007 Sep 15;43(6):959-67. doi: 10.1016/j.freeradbiomed.2007.06.004 Q18.22025

Cellular prion protein protects against reactive-oxygen-species-induced DNA damage

细胞型朊病毒蛋白能防止活性氧诱导的DNA损伤 翻译改进

Nicole T Watt  1, Michael N Routledge, Christopher P Wild, Nigel M Hooper

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  • 1 Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.
  • DOI: 10.1016/j.freeradbiomed.2007.06.004 PMID: 17697940

    摘要 Ai翻译

    Although the cellular form of the prion protein (PrPC) is critical for the development of prion disease through its conformational conversion into the infectious form (PrPSc), the physiological role of PrPC is less clear. Using alkaline single-cell gel electrophoresis (the Comet assay), we show that expression of PrPC protects human neuroblastoma SH-SY5Y cells against DNA damage under basal conditions and following exposure to reactive oxygen species, eith... ...点击完成人机验证后继续浏览
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    期刊名:Free radical biology and medicine

    缩写:FREE RADICAL BIO MED

    ISSN:0891-5849

    e-ISSN:1873-4596

    IF/分区:8.2/Q1

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    Cellular prion protein protects against reactive-oxygen-species-induced DNA damage