HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B
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Herein, we show that PTX-B and its non-toxic mutant PT9K/129G inhibit transcription and secretion of TGF-beta elicited by HIV-1 Tat in NK cells. Moreover, Tat strongly activates the cJun component of the multimolecular complex AP-1, while TGF-beta triggers cFo... ...
