Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles
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The aim of this paper was to investigate if the immunostimulatory effects of CpG-oligonucleotides (CpG-ODN) can be enhanced by the use of biodegradable protamine nanoparticles (proticles). We analyzed size, surface charge, and morphology of protamine nanoparti... ...