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Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells

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In the chemotherapeutic treatment of patients with disseminated neoplasms, multidrug resistance (MDR) is a major obstacle. ABCG2 (BCRP/MXR), a member of the superfamily of adenosine triphosphate-binding cassette (ABC) transporters, was demonstrated to be assoc... ...