Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties
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Angiotensin-converting enzyme (ACE) exists as two isoforms: somatic ACE (sACE), comprised of two homologous N and C domains, and testis ACE (tACE), comprised of the C domain only. The N and C domains are both active, but show differences in substrate and inhib... ...
