The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) and its typ I (PAC1) receptor expression in adult rat testes. Ethanol (3 g/kg i.p., 15% v/v in saline) was administrated to adult male rats for 10 days. Using northern blot analysis, the present study showed the reduction of PACAP mRNA levels in rat testes by ethanol administration. Also, ethanol decreased the expression level of PAC1 receptor in testes. In particular, in situ hybridization clearly showed the decrease of PAC1 receptor mRNA expression in Leydig cells, which produce testosterone. Furthermore, the serum level of testosterone was significantly decreased in the ethanol-treated group. In conclusion, our findings suggest that the decrease of PACAP and PAC1 receptor expression in rat testes by ethanol exposure may partly contribute to the suppression of male reproductive activity.
The Journal of veterinary medical science. 2006 Jun;68(6):537-41. doi: 10.1292/jvms.68.537 Q31.12024
Decrease of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in rat testes by ethanol exposure
乙醇暴露降低大鼠睾丸腺苷酸环化酶激活多肽及其I型受体的mRNA表达 翻译改进
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DOI: 10.1292/jvms.68.537 PMID: 16820708
摘要 Ai翻译
Keywords：ethanol exposure; testes mRNA
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