Metal ion-mediated reduction in surface entropy improves diffraction quality of crystals of the IRAK-4 death domain
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Interleukin-1 receptor-associated kinase-4 (IRAK-4) is an essential component of innate immunity in mice and humans. IRAK-4 is a bipartite protein composed of a death domain (DD) that mediates molecular recognition, and a catalytic kinase domain. Structure det... ...