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The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses

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Background: Tenofovir disoproxil fumarate, a prodrug of the nucleotide reverse transcriptase inhibitor, tenofovir (9-[9(R)-2-(phosphonomethoxy)propyl]adenine; PMPA), was recently approved for use in the combination therapy of hum... ...