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Carcinogenesis. 2005 Aug;26(8):1473-80. doi: 10.1093/carcin/bgi087 Q22.92025

Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells

定量性状基因座分析揭示了两个影响外周血单个核细胞O6-烷基鸟嘌呤-DNA-烷基转移酶活性的基因内位点 翻译改进

Geoffrey P Margison  1, Jim Heighway, Steven Pearson, Gail McGown, Mary R Thorncroft, Amanda J Watson, Kathryn L Harrison, Sarah J Lewis, Klaus Rohde, Philip V Barber, Paul O'Donnell, Andrew C Povey, Mauro F Santibáñez-Koref

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  • 1 Cancer Research-UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. gmargison@picr.man.ac.uk
  • DOI: 10.1093/carcin/bgi087 PMID: 15831531

    摘要 Ai翻译

    The repair of specific types of DNA alkylation damage by O6-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the carcinogenic and chemotherapeutic effects of certain alkylating agents. MGMT expression levels vary widely between individuals but the underlying causes of this variability are not known. To address this, we used an expressed single nucleotide polymorphism (SNP) and demonstrated that the MGMT alleles are frequently ... ...点击完成人机验证后继续浏览
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    期刊名:Carcinogenesis

    缩写:CARCINOGENESIS

    ISSN:0143-3334

    e-ISSN:1460-2180

    IF/分区:2.9/Q2

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    Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells