Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase
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The mini-chain of human cathepsin H has been identified as the major structural element determining the protease's substrate specificity. A genetically engineered mutant of human cathepsin H lacking the mini-chain, des[Glu(-18)-Thr(-11)]-cathepsin H, exhibits ... ...
