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The Journal of nutrition. 2002 May;132(5):1012-7. doi: 10.1093/jn/132.5.1012 Q23.82025

The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation

短链脂肪酸对人类结肠癌细胞表型的影响与组蛋白过度乙酰化相关 翻译改进

Brian F Hinnebusch  1, Shufen Meng, James T Wu, Sonia Y Archer, Richard A Hodin

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  • 1 Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • DOI: 10.1093/jn/132.5.1012 PMID: 11983830

    摘要 Ai翻译

    The short-chain fatty acid (SCFA) butyrate is produced via anaerobic bacterial fermentation within the colon and is thought to be protective in regard to colon carcinogenesis. Although butyrate (C4) is considered the most potent of the SCFA, a variety of other SCFA also exist in the colonic lumen. Butyrate is thought to exert its cellular effects through the induction of histone hyperacetylation. We sought to determine the effects of a variety of the SCFA ... ...点击完成人机验证后继续浏览
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    期刊名:Journal of nutrition

    缩写:J NUTR

    ISSN:0022-3166

    e-ISSN:1541-6100

    IF/分区:3.8/Q2

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    The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation