Reproductive capacity in women declines dramatically beyond the fourth decade of life. Oocyte quality seems to be the primary determinant of reproductive potential, although age-related uterine changes may also contribute. Underlying reasons for reproductive decline in women remain unclear, and both ovarian and neuroendocrine mechanisms have been proposed.A number of age-related endocrinologic changes precede menopause and predict diminished reproductive capacity. Thus, "ovarian reserve" screening may identify patients in whom attempts at conventional assisted reproduction is warranted before proceeding with ovum donation. Techniques to preserve the maternal genetic contribution to offspring (in lieu of egg donation), including germinal vesicle transfer and donor ooplasm, are under investigation.
Comparative Study American journal of obstetrics and gynecology. 2001 Sep;185(3):758-70. doi: 10.1067/mob.2001.114689 Q18.42025
Assessing fertility in women of advanced reproductive age
评估高龄女性的生育能力 翻译改进
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DOI: 10.1067/mob.2001.114689 PMID: 11568811
摘要 Ai翻译
Keywords：advanced reproductive age; fertilityassessment
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