Infectious transcripts from the full-length infectious clone of the NADL strain of bovine viral diarrhea virus (BVDV) were used to vaccinate cattle and sheep against BVDV. In vitro synthesized RNA delivered by microparticle bombardment with a Helios Gene Gun initiated replication of BVDV and consequently induced humoral immunity against type I BVDV (serum neutralization titers, SNT > 2(12)) and type II BVDV (SNT > 2(7)). The quality and long-term stability of the RNA-carrier complexes was assessed by microparticle bombardment of tissue culture monolayers. The RNA cartridges were found to be stable for at least 8 months upon storage. This is the first report on successful RNA vaccination of large ruminants.
Vaccine. 2001 Feb 28;19(15-16):2012-9. doi: 10.1016/s0264-410x(00)00438-2 Q23.52025
Microparticle-mediated RNA immunization against bovine viral diarrhea virus
微粒介导的牛病毒性腹泻病毒RNA免疫学 翻译改进
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DOI: 10.1016/s0264-410x(00)00438-2 PMID: 11228372
摘要 Ai翻译
Keywords：bovine viral diarrhea virus
关键词：微粒介导的RNA免疫; 牛病毒性腹泻病毒
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