Changing addictive behaviors may be conceptualized as a stage phenomenon consisting of precontemplation, contemplation, preparation, action, and maintenance stages. Prior research has provided empirical support for the existence of two discrete motivational subtypes of alcohol-dependent patients (i.e., precontemplation and contemplation/action stage patients). The present study attempted to identify similar motivational profiles for polysubstance-dependent patients and to provide empirical support for the validity of these profiles. Results from a sample of polysubstance-dependent VA patients revealed two clusters consistent with precontemplation (n = 62) and contemplation/action stage (n = 71) profiles, similar to findings from alcohol-dependent samples. Although, as expected, contemplation/action stage patients were more likely to complete treatment than were precontemplators, relatively few differences were noted between these two groups on several other theoretically relevant variables. These results suggest that these subtypes may not identify clinically similar types of patients across alcohol- and polysubstance-dependent samples.