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Induction of calcium-dependent action potentials by 4-aminopyridine in potassium depolarized guinea-pig papillary muscle

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Exposure of guinea-pig papillary muscle to 22 mM K+ resulted in loss of electromechanical excitability accompanied by an elevation of mean electrical threshold by 8.96 V and a membrane depolarization of about 47.3 mV. After setting the threshold to a new sensi... ...