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Evidence that presynaptic changes are involved in the expression of LTP and LTD of NMDA receptor-mediated EPSCs in area CA1 of the hippocampus

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Plasticity of NMDA receptor-mediated synaptic transmission was studied in the CA1 region of the hippocampus utilising whole cell patch-clamp recording techniques. LTP was associated with a decrease in CV whereas LTD was accompanied by an increase in CV and a d... ...