ZPR1 is a zinc finger protein that binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Deletion analysis demonstrated that this binding interaction is mediated by the zinc fingers of ZPR1 and subdomains X and XI of the EGFR tyrosine kinase. Treatment of mammalian cells with EGF caused decreased binding of ZPR1 to the EGFR and the accumulation of ZPR1 in the nucleus. The effect of EGF to regulate ZPR1 binding is dependent on tyrosine phosphorylation of the EGFR. ZPR1 therefore represents a prototype for a class of molecule that binds to the EGFR and is released from the receptor after activation.
Science (New York, N.Y.). 1996 Jun 21;272(5269):1797-802. doi: 10.1126/science.272.5269.1797 Q144.82024
Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor
锌指蛋白ZPR1与表皮生长因子受体的结合 翻译改进
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DOI: 10.1126/science.272.5269.1797 PMID: 8650580
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Keywords：zinc finger protein
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