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Thapsigargin inhibits the effects of noradrenaline and high [Ca2+]o on kinetics but not on amplitude of contraction in the single myocytes of guinea-pig heart

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We investigated the effect of selective blocker of Ca(2+)-ATPase of sarcoplasmic reticulum (SR), thapsigargin (TG), on the responses of single myocytes of guinea-pig heart to high [Ca2+]o and noradrenaline (NA). The cells were loaded with acetomethylester of I... ...