Mitochondrial synthesis of subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria in the perfused heart was measured under four different conditions; low heart rate (HR) and low peak left ventricular systolic pressure (PLVSP), low HR and high PLVSP, high HR and low PLVSP, and high HR and high PLVSP. The SS mitochondria exhibited the greatest rate of synthesis under all conditions, although the percentage of change from simulated resting state a low HR and low PLVSP varied with the workload. These data suggest a specificity of function of mitochondria determined by subcellular localization and myocardial workload.
Research communications in chemical pathology and pharmacology. 1981 Oct;34(1):157-60.
Myocardial mitochondrial synthesis in response to various workloads
不同负荷下的心肌线粒体生物合成响应规律研究 翻译改进
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PMID: 7313299
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