Several N,N'-bis(arylsulfonyl)hydrazines, with the potential to function as biological methylating agents, were synthesized and evaluated for antineoplastic activity against the L1210 leukemia and other transplanted rodent tumors. In general, the N-methyl-N,N'-bis(arylsulfonyl)hydrazines that possess the capacity to generate an alkylating species under physiological conditions showed significant antineoplastic activity, while N,N'-bis(phenylsulfonyl)-hydrazine and N-methyl-N,N'-dibenzoylhydrazine were inactive.
Journal of medicinal chemistry. 1985 Apr;28(4):525-7. doi: 10.1021/jm00382a027 Q16.82025
Synthesis and evaluation of N,N'-bis(arylsulfonyl)hydrazines as antineoplastic agents
N,N'-双芳基磺酰基肼的合成及其作为抗肿瘤剂的应用评价研究 翻译改进
K Shyam, L A Cosby, A C Sartorelli
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DOI: 10.1021/jm00382a027 PMID: 3981547
摘要 Ai翻译
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