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Environmental mutagenesis. 1986;8(5):705-15. doi: 10.1002/em.2860080506

Patterns of mutagen binding and penetration in multicell spheroids

诱变剂在多细胞球体内的结合及渗透规律研究 翻译改进

P L Olive

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DOI: 10.1002/em.2860080506 PMID: 3095108

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Mutagen damage to a cell located at some distance from the site of application of the mutagen will depend, in part, on how effectively it can penetrate through cells composing different tissues. Chinese hamster V79 spheroids were used to model mutagen "penetrability" by providing several layers of cells growing with tissue-like packing. By treating cells of intact and trypsin-dissociated spheroids at the same drug-to-cell ratio, an estimate relative sensit... ...点击完成人机验证后继续浏览
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Patterns of mutagen binding and penetration in multicell spheroids