Vinblastine selectively inhibits the activation of brain cyclic AMP phosphodiesterase activity by Ca++-protein activator (50% inhibition by 2 x 10(-5) M). This inhibitory effect was reversed by excessive amounts of the activator, whereas large quantities of Ca++ caused only a slight suppression of the vinblastine effect. This result of vinblastine suggests a new site of its action and also suggests the possible role of protein activator, phosphodiesterase proteins or cyclic nucleotides in the previously known effects of vinblastine in vivo and in vitro.
Experientia. 1979 Nov 15;35(11):1487-9. doi: 10.1007/BF01962801
Specific inhibition of a calcium dependent activation of brain cyclic AMP phosphodiesterase activity by vinblastine
长春新碱特异性抑制脑内钙依赖性环核苷酸磷酸二酯酶活性的作用 翻译改进
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DOI: 10.1007/BF01962801 PMID: 228966
摘要 Ai翻译
Keywords：calcium dependent activation
关键词：环AMP磷酸二酯酶活性; 钙依赖激活
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